ADI
Archives of Drug Information (ADI) is a new open access, peer reviewed-journal, dedicated to rapid publication of the results of drug trials.
ADI will consider: clinical studies including those deemed ‘low priority’ by other journals, negative and ‘null’ studies, early PK drug development studies, routine PH or interaction studies, dose finding studies, animal toxicity studies, and pilot studies.
ADI allows the pharmaceutical industry to publish articles in a peer-reviewed, unbiased journal, easily accessible to drug development scientists and the public around the world.
Read ‘ADI: A New Approach to Publishing the Results of Drug Studies’ by C Michael Stein
Highlights from ADI
1.
Utility of Pretreatment Bilirubin Level and UGT1A1 Polymorphisms in Multivariate Predictive Models of Neutropenia Associated with Irinotecan Treatment in Previously Untreated Patients with Colorectal Cancer
Laura A. Cisar, Doug Lee, Luis Parodi, Eve Pickering, Raoudha Soufi-Mahjoubi
Purpose. Statistical models for predicting hematologic toxicity were evaluated based on UGT1A1 polymorphisms and baseline serum bilirubin.Methods. Blood DNA samples were collected from 113 patients with untreated metastatic colorect...
Latest articles from ADI
1.
Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers
Susan Grange, Myriam Riek, Christophe Schmitt, Malte Schutz, Katie Winters
Objectives. Rifampin is a potent inducer of the cytochrome P450 3A4 isoenzyme (CYP3A4) that metabolizes most protease inhibitor (PI) antiretrovirals. This study was designed to evaluate the steady-state pharmacokinetics and tolerability ...
2.
Probiotic Pre-treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats
Hani Al-Salami, Grant Butt, Svetlana Golocorbin-Kon, Momir Mikov, Ranko Skrbic, Ian Tucker
Aim. To investigate the influence of probiotic pre-treatment on the permeation of the antidiabetic drug gliclazide in healthy and diabetic rats.Methods. Wistar rats (age 2–3 months, weight 350 ± 50 g) were...
3.
Left Ventricular Diastolic Function in Nigerian Patients with Essential Hypertension: A Retrospective Study to Compare Angiotensin Converting Enzyme Inhibitors, Calcium Channel Blockade or Their Combination
Adegboyega Q. Adigun, Adesuyi A. L. Ajayi, Olufemi E. Ajayi, Anthony O. Akintomide
Background. Hypertension in blacks imposes a greater left ventricular hypertrophy, and accelerated heart failure onset. We evaluated and compared the echocardiographically determined systolic and left ventricular diastolic functional ind...
